Alcohol use during pregnancy can cause miscarriage, stillbirth, and a range of behavioral, intellectual, and physical disabilities known as fetal alcohol spectrum disorders (FASDs). While evidence-based approaches to decreasing alcohol use during pregnancy exist, research suggests healthcare professionals (HCPs) are implementing them inconsistently and ineffectually. To address this issue, in 2020, CDC’s National Center on Birth Defects and Developmental Disabilities (NCBDDD) selected Oak Ridge Associated Universities (ORAU) to conduct message testing and develop communication materials. This effort has produced a suite of “Let’s Talk” materials for HCPs in multiple formats for a variety of communication channels. The materials assist HCPs in 1) engaging in open conversations and shared decision-making with their patients regarding alcohol use in general and during pregnancy and 2) incorporating alcohol screening and brief intervention (SBI) into their daily practices. The theme of this presentation is how to best provide communication assistance to HCPs on these important topics. The purpose of this panel is to share both our message-testing findings and process insights from our "Let's Talk" project. We will highlight the project's innovative use of asynchronous, online, moderated discussion boards as a data collection method, as well as our development of a National Partner Network digital toolkit to enhance dissemination to key audiences. Our discussion of the “Let’s Talk” communication materials will also highlight how FASD prevention messaging has evolved over time, current communication challenges, and future communication goals related to alcohol use during pregnancy.